2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W015224S
    Methyl 2-(1H-indol-3-yl)acetate-d5 102415-39-4 98%
    Methyl 2-(1H-indol-3-yl)acetate-d5 is the deuterium labeled Methyl 2-(1H-indol-3-yl)acetate. Methyl 2-(1H-indol-3-yl)acetate is an endogenous metabolite.
    Methyl 2-(1H-indol-3-yl)acetate-d5
  • HY-W015240R
    N-Acetyl-L-glutamic acid (Standard) 1188-37-0
    N-Acetyl-L-glutamic acid (Standard) is the analytical standard of N-Acetyl-L-glutamic acid (HY-W015240). This product is intended for research and analytical applications. N-Acetyl-L-glutamic acid is a type of glutamic acid that can serve as a component of cell culture media. When combined with media containing inorganic salts, carbohydrates, vitamins, and amino acids, N-Acetyl-L-glutamic acid plays roles in promoting cell growth, enhancing antibody production, etc. N-Acetyl-L-glutamic acid is also an endogenous metabolite that can be found in the brain. Additionally, as an IgE blocker, N-Acetyl-L-glutamic acid can be used in the research of allergic diseases.
    N-Acetyl-L-glutamic acid (Standard)
  • HY-W015273S
    3-Indoleacrylic acid-d4 98%
    3-Indoleacrylic acid-d4 is deuterium labeled 3-Indoleacrylic acid (HY-W015273). 3-Indoleacrylic acid is a high-efficient antialgal agent. 3-Indoleacrylic acid increases reactive oxygen species (ROS) production, and inhibits the functions of all the nutrient assimilating genes, down-regulated ribulose-1,5-bisphosphate carboxylase/oxygenase II, and cytochrome f genes in P. donghaiense.
    3-Indoleacrylic acid-d4
  • HY-W015342R
    Methyl anisate (Standard) 121-98-2
    Methyl anisate (Standard) is the analytical standard of Methyl anisate. This product is intended for research and analytical applications. Methyl anisate is an endogenous metabolite.
    Methyl anisate (Standard)
  • HY-W015444R
    2-Hydroxyoctanoic acid (Standard) 617-73-2
    2-Hydroxyoctanoic acid (Standard) is the analytical standard of 2-Hydroxyoctanoic acid. This product is intended for research and analytical applications. 2-Hydroxyoctanoic acid is a medium chain acyl-CoA synthetase inhibitor with a Ki of 500 μM[1].
    2-Hydroxyoctanoic acid (Standard)
  • HY-W015464R
    N-Isovaleroylglycine (Standard) 16284-60-9
    N-Isovaleroylglycine (Standard) is the analytical standard of N-Isovaleroylglycine. This product is intended for research and analytical applications. N-Isovaleroylglycine is an acyl glycine and could be used as a biomarker for the predispositon for weight gain and obesity.
    N-Isovaleroylglycine (Standard)
  • HY-W015464S
    N-Isovalerylglycine-d9 1330037-21-2 ≥99.0%
    N-Isovalerylglycine-d9 is the deuterium labeled N-Isovaleroylglycine. N-Isovaleroylglycine is an acyl glycine and could be used as a biomarker for the predispositon for weight gain and obesity.
    N-Isovalerylglycine-d9
  • HY-W015618R
    2',4'-Dimethylacetophenone (Standard) 89-74-7
    Nefopam (hydrochloride) (Standard) is the analytical standard of Nefopam (hydrochloride). This product is intended for research and analytical applications. Nefopam hydrochloride (Fenazoxine hydrochloride) is a centrally-acting but non-opioid analgesic drug, for the relief of moderate to severe pain. Nefopam hydrochloride targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo.
    2',4'-Dimethylacetophenone (Standard)
  • HY-W015675R
    4-Hydroxycyclohexanecarboxylic acid (Standard) 17419-81-7
    Lasamide (Standard) is the analytical standard of Lasamide. This product is intended for research and analytical applications. Lasamide is a potent human Carbonic Anhydrase inhibitor with Ki values of 7.54 and 2.76 nM for hCAXII and hCAIX, respectively.
    4-Hydroxycyclohexanecarboxylic acid (Standard)
  • HY-W015780S
    1,4-Dimethoxybenzene-d10 74079-00-8 98%
    1,4-Dimethoxybenzene-d10 is the deuterium labeled 1,4-Dimethoxybenzene. 1,4-Dimethoxybenzene is an endogenous metabolite.
    1,4-Dimethoxybenzene-d10
  • HY-W015851R
    (R)-3-Hydroxybutanoic acid sodium (Standard) 13613-65-5
    (R)-3-Hydroxybutanoic acid (sodium) (Standard) is the analytical standard of (R)-3-Hydroxybutanoic acid (sodium). This product is intended for research and analytical applications. (R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[1][2].
    (R)-3-Hydroxybutanoic acid sodium (Standard)
  • HY-W015851S
    3-Hydroxybutanoic acid-13C sodium 1173022-79-1 98%
    3-Hydroxybutanoic acid-13C-13C (sodium) is the 13C labeled 3-Hydroxybutanoic acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids.
    3-Hydroxybutanoic acid-13C sodium
  • HY-W015874R
    2-Hydroxy-2-methylbutanoic acid (Standard) 3739-30-8
    2-Hydroxy-2-methylbutanoic acid (Standard) is the analytical standard of 2-Hydroxy-2-methylbutanoic acid. This product is intended for research and analytical applications. 2-Hydroxy-2-methylbutanoic acid, an unusual metabolite, is associated with 2-hydroxyglutaric aciduria and maple syrup urine disease.
    2-Hydroxy-2-methylbutanoic acid (Standard)
  • HY-W015878R
    5-Aminovaleric acid (Standard) 660-88-8
    5-Aminovaleric acid (Standard) is the analytical standard of 5-Aminovaleric acid. This product is intended for research and analytical applications. 5-Aminovaleric acid is believed to act as a methylene homologue of gamma-aminobutyric acid (GABA) and functions as a weak GABA agonist.
    5-Aminovaleric acid (Standard)
  • HY-W015954R
    (2R,3R)-Butane-2,3-diol (Standard) 24347-58-8
    (2R,3R)-Butane-2,3-diol (Standard) is the analytical standard of (2R,3R)-Butane-2,3-diol (HY-W015954). This product is intended for research and analytical applications. (2R,3R)-Butane-2,3-diol is a non-covalent, reversible agonist targeting lanthanum (La3+)-sensitive calcium channels in bacteria (e.g., Escherichia coli) with an EC50 of approximately 25 mM. (2R,3R)-Butane-2,3-diol binds to calcium channel proteins or related complexes, induces channel opening, promotes extracellular calcium influx, and triggers intracellular calcium transients, which may regulate bacterial physiological activities such as growth, metabolism, and signal transduction. (2R,3R)-Butane-2,3-diol mediates bacterial-host cell signaling interactions and affects the metabolic balance of intestinal microorganisms, and can be used to study lactose intolerance and other related diseases.
    (2R,3R)-Butane-2,3-diol (Standard)
  • HY-W015969R
    1-Aminopropan-2-ol (Standard) 78-96-6
    1-Aminopropan-2-ol (Standard) is the analytical standard of 1-Aminopropan-2-ol. This product is intended for research and analytical applications. 1-Aminopropan-2-ol is a microbial metabolism of amino alcohol metabolism via propionaldehyde and acetaldehyde in a species of Pseudomonas.
    1-Aminopropan-2-ol (Standard)
  • HY-W016009S
    2'-Deoxyadenosine-5'-monophosphate-d12 dilithium
    2'-Deoxyadenosine-5'-monophosphate-d12 dilithium is deuterium labeled 2'-Deoxyadenosine-5'-monophosphate (HY-W016009). 2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage.
    2'-Deoxyadenosine-5'-monophosphate-d12 dilithium
  • HY-W016409R
    Ethyl 3,4-dihydroxybenzoate (Standard) 3943-89-3
    Ethyl 3,4-dihydroxybenzoate (Standard) (Protocatechuic acid ethyl ester (Standard)) is the analytical standard of Ethyl 3,4-dihydroxybenzoate (HY-W016409). This product is intended for research and analytical applications. Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema.
    Ethyl 3,4-dihydroxybenzoate (Standard)
  • HY-W016628R
    L-Gulono-1,4-lactone (Standard) 1128-23-0
    L-Gulono-1,4-lactone (Standard) is the analytical standard of L-Gulono-1,4-lactone. This product is intended for research and analytical applications. L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.
    L-Gulono-1,4-lactone (Standard)
  • HY-W016647R
    For-Met-OH (Standard) 4289-98-9
    For-Met-OH (Standard) is the analytical standard of For-Met-OH. This product is intended for research and analytical applications. For-Met-OH is an endogenous metabolite.
    For-Met-OH (Standard)
Cat. No. Product Name / Synonyms Application Reactivity